	

Product Number: 	*85590* 	 
Product Name: 	*Spermine*



Valid 05/2003 - 07/2003

Sigma-Aldrich Chemie B.V.
Stationsplein 4, Postbus 27
NL-3330 AA Zwijndrecht Nederland
tel.: (31)-(0)78-6205411
gratis tel.: 0800-0229088




             M A T E R I A L  S A F E T Y  D A T A  S H E E T
             
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
    CATALOG #:            85590
    NAME:                 SPERMINE*
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
    CAS #:    71-44-3
    MF: C10H26N4
    EC NO:  200-754-2
  SYNONYMS
    N,N'-BIS(3-AMINOPROPYL)-1,4-BUTANEDIAMINE * N,N'-BIS(3-AMINOPROPYL)-1,
    4-TETRAMETHYLENEDIAMINE * 1,4-BIS(AMINOPROPYL) BUTANEDIAMINE * 1,4-
    DIAMINOBUTANE, N,N'-BIS(3-AMINOPROPYL)- *
    DIAMINOPROPYLTETRAMETHYLENEDIAMINE * 4,9-DIAZA-1,12-DODECANEDIAMINE *
    GERONTINE * MUSCULAMINE * NEURIDINE * SPERMINE * SPERMINE, PURISS * 1,
    5,10,14-TETRAZAZTETRADECANE *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
  LABEL PRECAUTIONARY STATEMENTS
    CORROSIVE
    CAUSES BURNS.
    IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
    WATER AND SEEK MEDICAL ADVICE.
    WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
    PROTECTION.
    IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
    IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
    IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
    CALL A PHYSICIAN IMMEDIATELY.
    DO NOT INDUCE VOMITING.
    IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
    RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
    IN CASE OF SKIN CONTACT, FLUSH WITH COPIOUS AMOUNTS OF WATER
    FOR AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND
    SHOES. CALL A PHYSICIAN.
    IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF WATER
    FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING
    THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
  EXTINGUISHING MEDIA
    CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
  SPECIAL FIREFIGHTING PROCEDURES
    WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
    PREVENT CONTACT WITH SKIN AND EYES.
  UNUSUAL FIRE AND EXPLOSIONS HAZARDS
    EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
    WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY
    RUBBER GLOVES.
    SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
    VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
    EVACUATE AREA.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
    REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
    SAFETY SHOWER AND EYE BATH.
    USE ONLY IN A CHEMICAL FUME HOOD.
    WASH CONTAMINATED CLOTHING BEFORE REUSE.
    DISCARD CONTAMINATED SHOES.
    WASH THOROUGHLY AFTER HANDLING.
    DO NOT BREATHE DUST.
    DO NOT GET IN EYES, ON SKIN, ON CLOTHING.
    AVOID PROLONGED OR REPEATED EXPOSURE.
    NIOSH/MSHA-APPROVED RESPIRATOR.
    COMPATIBLE CHEMICAL-RESISTANT GLOVES.
    CHEMICAL SAFETY GOGGLES.
    KEEP TIGHTLY CLOSED.
    STORE IN A COOL DRY PLACE.
    REFRIGERATE.
    STORE UNDER NITROGEN.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
  PHYSICAL PROPERTIES
    BOILING POINT:        130  C
    MELTING POINT:      28 - 30  C
    FLASHPOINT               >230F
                             >110C
    SPECIFIC GRAVITY:     0.937
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
  STABILITY
    STABLE.
  CONDITIONS TO AVOID
    ABSORBS CO2 FROM AIR.
  INCOMPATIBILITIES
    SENSITIVE TO MOISTURE
    ACIDS
    ACID CHLORIDES
    ACID ANHYDRIDES
    OXIDIZING AGENTS
  HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
    THERMAL DECOMPOSITION MAY PRODUCE CARBON MONOXIDE, CARBON DIOXIDE,
    AND NITROGEN OXIDES.
  HAZARDOUS POLYMERIZATION
    WILL NOT OCCUR.
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
  ACUTE EFFECTS
    CAUSES BURNS.
    MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.
    MATERIAL IS EXTREMELY DESTRUCTIVE TO THE TISSUE OF THE MUCOUS MEMBRANES
    AND UPPER RESPIRATORY TRACT.
    MAY BE HARMFUL IF INHALED.
    MAY BE HARMFUL IF SWALLOWED.
    INHALATION MAY RESULT IN SPASM, INFLAMMATION AND EDEMA OF THE
    LARYNX AND BRONCHI, CHEMICAL PNEUMONITIS AND PULMONARY EDEMA.
    SYMPTOMS OF EXPOSURE MAY INCLUDE BURNING SENSATION, COUGHING,
    WHEEZING, LARYNGITIS, SHORTNESS OF BREATH, HEADACHE, NAUSEA AND
    VOMITING.
    MATERIAL IS EXTREMELY DESTRUCTIVE TO TISSUE OF THE MUCOUS MEMBRANES
    AND UPPER RESPIRATORY TRACT, EYES AND SKIN.
    TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND
    TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.
  RTECS #: EJ7175000
    1,4-BUTANEDIAMINE, N,N'-BIS(3-AMINOPROPYL)-
  TOXICITY DATA
    IPR-RAT LD50:33 MG/KG                         TXAPA9 88,433,1987
    IVN-RAT LD50:65 MG/KG                         AIPTAK 165,374,1967
    IVN-MUS LD50:56 MG/KG                         CSLNX* NX#00641
  TARGET ORGAN DATA
    BEHAVIORAL (SOMNOLENCE)
    BEHAVIORAL (CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD)
    BEHAVIORAL (CHANGE IN MOTOR ACTIVITY)
    LUNGS, THORAX OR RESPIRATION (DYSPNAE)
    LUNGS, THORAX OR RESPIRATION (OTHER CHANGES)
    KIDNEY, URETER, BLADDER (CHANGES IN TUBULES)
    NUTRITIONAL AND GROSS METABOLIC (DEHYDRATION)
    NUTRITIONAL AND GROSS METABOLIC (BODY TEMPERATURE DECREASE)
    ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
    (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
    COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
    DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
    CONTACT A LICENSED PROFESSIONAL WASTE DISPOSAL SERVICE TO DISPOSE OF
    THIS MATERIAL.
    OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
    CONTACT FLUKA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
  EUROPEAN INFORMATION
    CORROSIVE
    R 34
    CAUSES BURNS.
    S 26
    IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
    WATER AND SEEK MEDICAL ADVICE.
    S 36/37/39
    WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
    PROTECTION.
    S 45
    IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
    IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
  REVIEWS, STANDARDS, AND REGULATIONS
    OEL=MAK
    EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
    THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
    BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
    FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
    OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
    PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
    COPYRIGHT 2001 SIGMA-ALDRICH CO.
    LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY





